What is meant by B tooling D tooling DB tooling and BB tooling dies and punches in tablet compression machine

Tablet tooling.

B tooling D tooling DB tooling and BB tooling dies and punches

Tablet compression machines are made in keeping in view the type of dies and punches will be used on them, speed at which it will be operated. The dies and punches and their setup on compression machine is called tooling , it is classified as B and D mainly .
The B tooling dies and punch can be further have specifications as BB and D tooling can also be dies and punches can be utilzed on B tooling machine which is called as DB

Mainly there are two standards, ad D and B , in US specification provided by Tableting Specification Manual (TSM )is followed where as in Europe European standard known as the EU, or "Euronorm" standard is.
There is not much difference in both the specifications but both are very different.

Difference between B and D tooling
Following is the key difference between D and B tooling for tablets compression
D tooling
Barel Diameter is 1 inch
Head Diameter is 1 and ¼ th inch length is 5.25 inch
Dies outer diameter is 0.945 and
BB Tolling
Barel Diameter is 0.75 inch
Head Diameter is 1 inch length is 5.25 inch
Dies outer diameter is 30.16 mm
B tooling is same as BB only difference is that lower punch length is just 3 and 9/16th inch long.
D tooling dies and punches are usually have thick diameter or have greater diameter of their body as well as the tip of punches also dies have greater outer diameter compared to B type tolling which makes D type tolling dies and punches suitable for compression of big size tablets as the tip of the pinches is border compared to B tooling dues and punches.
Many sub categories like DB , BB type tablets dies and punches are made depending up on the punches and dies requirement of product.
Following table will be useful in understanding the concept of tablet tooling and how they are classified as B and D tooling and BB and DB tooling.

You may like this which has great resource for Pharma Industry professionals.

TimesofPharma Pharma Guide for Industry professionals  

Osmotically controlled drug releasing tablets dosage form laser drilled tablet

Lesser drilled tablets osmotically controlled drug releasing tablets dosageform
Controlled release of a particular drug is required in some patient to achieve optimum therapeutic action, which can be achieved by
1) Sustained drug delivery tablets.
2) Delayed drug delivery tablets.
3) Osmoticaly Controlled Tablets dosage form

When only drug release is to be sustained for long period of time a matrix system that holds drug and releases in steady pattern from its matrix by osmosis, dissolution is adapted. HPMC and CMC polymers dispersed are formed.

Osmotic tablets technology:
1) Tablets are coated with a semi pemiable membrane and a small hole is drilled on one surface of the tablet. Hole on tablet surface is drilled with the help of lesser beam. One can control the size of the hole of surface of table by considering the rate of drug dissolution and permeation through the hole.
2) asymmetric-membrane technology (AMT) : In this technology a micro porous membrane coating is done on the tablets which when administered release drug after sweeling of this membrane is achieved, drug release is almost zero order and steady.

Also see Validation in Pharma Industry
3) osmotic swellable core technology (SCT): This type of tablets are coated with semipermiable coating, tablet consist of two layers, 1) one layer of drug molecule, on the face of which a small hole is drilled. 2) A swellable polymer when comes in contact with water swells and create a pressure inside table pushing other layer of drug to release from the lesser drilled pore.
These type of tablets have wide range drug delivery pattern, by choosing a best fit swelling polymer and controlling the size of lesser drilled pore on tablet.
Drug release from these type of tablets is steady and almost can be comparable with in vivo to invitro results of dissolution and absorption of drug molecule.

Clean room classification Pharma      

Laser drilling on tablets can be achieved by machines available which make use of round turret and a tablet pass under lesser beam where in a hole is drilled, before drilling hole machine have a sensor for detecting correct face for drilling hole on tablet coat. Further inspection on camera is done for tablets to ensure the same.

Drug saftey alert about Ketoconazole Tablet

Drug safety alert By USFDA: ketoconazole tables use orally to treat Fungal infection on Skin and nail. is associated with loss of lives due to serious liver damage and adrenalin gland abnormalities. USFDA has mentioned brand Nizoral of Pfizer in its drug safety communication on its site. Topical dosage form of drug Ketoconazole is safe for these indications, it donot exhibit such adverse effect like those reported for oral dosage form. This is because toxic metabolites are not generated in liver as drug escapes its first pass metabolism in liver when used topically, and amount of drug passing in to systemic circulation too is low.