Tablets Dosage form is one of a most prefered dosage form all over the world

Almost all drug molecules can be formulated in a tablet and process of manufactiring of tablets too is very simple , and is very flexible.

One can administere 0.01 mg of a drug dose to 1 gm of a drug dose by oral route of administration , by formulating as a tablet.

We have decided to write about tablets manufacturing , formulations.

You will find our articles very intresting as , we are writng out of our experience of actual manufacturing of about 1000 different formulations and drugs , and not merily with therotical experience.

We will provide here on this blog case studies of tablets formulations , trouble shooting , development , tablets machineries tools and many intresting things about tablets formulations and tablets coating , our blog will guide for developing a cost effective and cheaper tablet coating materials .

Saturday, June 25, 2016

Osmotically controlled drug releasing tablets dosage form

Lesser drilled tablets osmotically controlled drug releasing tablets dosageform
Controlled release of a particular drug is required in some patient to achieve optimum therapeutic action, which can be achieved by
1) Sustained drug delivery tablets.
2) Delayed drug delivery tablets.
3) Osmoticaly Controlled Tablets dosage form

When only drug release is to be sustained for long period of time a matrix system that holds drug and releases in steady pattern from its matrix by osmosis, dissolution is adapted. HPMC and CMC polymers dispersed are formed.
Leser drilled tablets osmotic drug release system

Osmotic tablets technology:
1) Tablets are coated with a semi pemiable membrane and a small hole is drilled on one surface of the tablet. Hole on tablet surface is drilled with the help of lesser beam. One can control the size of the hole of surface of table by considering the rate of drug dissolution and permeation through the hole.
2) asymmetric-membrane technology (AMT) : In this technology a micro porous membrane coating is done on the tablets which when administered release drug after sweeling of this membrane is achieved, drug release is almost zero order and steady.
3) osmotic swellable core technology (SCT): This type of tablets are coated with semipermiable coating, tablet consist of two layers, 1) one layer of drug molecule, on the face of which a small hole is drilled. 2) A swellable polymer when comes in contact with water swells and create a pressure inside table pushing other layer of drug to release from the lesser drilled pore.
These type of tablets have wide range drug delivery pattern, by choosing a best fit swelling polymer and controlling the size of lesser drilled pore on tablet.
Drug release from these type of tablets is steady and almost can be comparable with in vivo to invitro results of dissolution and absorption of drug molecule.
Leser drilled tablets

Laser drilling on tablets can be achieved by machines available which make use of round turret and a tablet pass under lesser beam where in a hole is drilled, before drilling hole machine have a sensor for detecting correct face for drilling hole on tablet coat. Further inspection on camera is done for tablets to ensure the same.

Saturday, May 21, 2016

Drug saftey alert about Ketoconazole Tablet

Drug safety alert By USFDA: ketoconazole tables use orally to treat Fungal infection on Skin and nail. is associated with loss of lives due to serious liver damage and adrenalin gland abnormalities. USFDA has mentioned brand Nizoral of Pfizer in its drug safety communication on its site. Topical dosage form of drug Ketoconazole is safe for these indications, it donot exhibit such adverse effect like those reported for oral dosage form. This is because toxic metabolites are not generated in liver as drug escapes its first pass metabolism in liver when used topically, and amount of drug passing in to systemic circulation too is low.