Sustained Release Dosage Forms

Sustained Release Dosage Forms
Another form of coating is enteric coated tablets which are coated with a material which will dissolve in the intestine but remain intact in the stomach. Polymeric acid compounds have been used for this purpose with some success. This topic and the area of sustained release products has been discussed in more detail in other courses. also see pharmaceutical validation
Benefits

for short half-life drugs, sustained release can mean less frequent dosing and thus better compliance.
reduce variations in plasma/blood levels for more consistent result.
Problems

More complicated formulation, may be more erratic in result. A sustained release product may contain a larger dose, i.e. the dose for two or three (or more) 'normal' dosing intervals. A failure of the controlled release mechanism may result in release of a large toxic dose.
more expensive technology also see validation
Types of products

erosion tablets
waxy matrix
matrix erodes or drug leaches from matrix
coated pellets
different pellets (colors) have different release properties
coated ion exchange

osmotic pump

.Pharma .blogspot.com

insoluble coat with small hole. Osmotic pressure pushes the drug out at a controlled rate.
Results - reduced side effects,this website www,tablets dosage form,blogspot,com is dedicated for educting pharmaceuticle students, also see process validation